Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer.
نویسندگان
چکیده
Chen AM , Farwell DG , Luu Q , Donald PJ , Perks J , Purdy J . [20] Evaluation of the planning target volume in the treatment of head and neck cancer with intensity-modulated radiotherapy: What is the appropriate expansion margin in the setting of daily image guidance? Int J Radiat Oncol Biol Phys 2011 ; 81 : 943 – 9 . Van Herk M , Remeijer P , Rasch C , Lebesque JV . The [21] probability of correct target dosage: Dose-population histograms for deriving treatment margins in radiotherapy . Int J Radiat Oncol Biol Phys 2000 ; 47 : 1121 – 35 . Giske K , Stoiber EM , Schwarz M , Stoll A , Muenter MW [22] Timke C, et al . Local setup errors in image-guided radiotherapy for head and neck cancer patients immobilized with a custom-made device . Int J Radiat Oncol Biol Phys 2011 ; 80 :582 – 9. normal tissue sparing with IMRT for head-and-neck cancer . Int J Radiat Biol Phys 2001 ; 51 : 1400 – 9 . Van Asselen B , Dehnad H , Raaijmakers CPJ , Roesik JM , [17] Lagendijk JJW , Terhaard CHJ . The dose to the parotid glands with IMRT for oropharyngeal tumors: The effect of reduction of positioning margins . Radiother Oncol 2002 ; 64 : 197 – 204 . Den RB , Doemer A , Kubicek G , Bednarz G , Galvin JM , [18] Keane WM , et al . Daily image guidance with cone-beam computed tomography for head-and-neck cancer intensitymodulated radiotherapy: A prospective study . Int J Radiat Oncol Biol Phys 2010 ; 76 : 1353 – 9 . Hong TS , Tome WA , Chappell RJ , Chinnaiyan P , Mehta MP , [19] Harari P . The impact of daily setup variations on head-andneck intensity-modulated radiation therapy . Int J Radiat Oncol Biol Phys 2005 ; 61 : 779 – 88 .
منابع مشابه
Treatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development
Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...
متن کاملPromising role for Gc-MAF in cancer immunotherapy: from bench to bedside
Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...
متن کاملO-3: Drug Repositioning by Merging Gene Expression Data Analysis and Cheminformatics Target Prediction Approaches
The transcriptional responses of drug treatments combined with a protein target prediction algorithm was utilised to associate compounds to biological genomic space. This enabled us to predict efficacy of compounds in cMap and LINCS against 181 databases of diseases extracted from GEO. 18/30 of top drugs predicted for leukemia (e.g. Leflunomide and Etoposide) and breast cancer (e.g. Tamoxifen a...
متن کاملIs Colorectal Cancer an Unusual Malignancy among Iranian Children?
Dear Editors: Adenocarcinoma of colon and rectum is the second most common cancer of the gastrointestinal (GI) tract in children. The development of carcinoma of colon in general appears to be associated with several predisposing factors such as familial polyposis, hereditary non-polyposis syndromes, ulcerative colitis, previous ureterosigmoidostomy or radiation therapy and dietary factors (hig...
متن کاملComparative Clinical Trial of Mebendazole, Praziquantel and Metronidazole in Treatment of Human Giardiasis
Background: Giardia lamblia is a common intestinal parasite associated with social or personal problems. Giardiasis is distributed all over the world; however, the infection is more prevalent in developing countries. Metronidazole is now considered as a drug of choice for giardiasis treatment. The increasing number of reports of refractory cases as well as side effects of this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta oncologica
دوره 53 3 شماره
صفحات -
تاریخ انتشار 2014